BDP8900 |CAS: 2226507-05-5 Probechem Biochemicals

Chemical Structure : BDP8900

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BDP8900 (BDP 8900;BDP-8900)

货号: PC-63522Not For Human Use, Lab Use Only.

BDP8900 (BDP-8900) is a highly potent and selective Myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with IC50 of 43 nM (MRCKβ), >100-fold selectivity over related ROCK1 or ROCK2.

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生物&药学活性

BDP8900 (BDP-8900) is a highly potent and selective Myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with IC50 of 43 nM (MRCKβ), >100-fold selectivity over related ROCK1 or ROCK2。
BDP8900 shows similar activity against MRCKα and MRCKβ。
BDP8900 displays consistent antiproliferative effects with greatest activity in hematologic cancer cells.

物理化学性质&存储条件

分子量	353.488
分子式	C19H23N5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(4-(1,8-diazaspiro[5.5]undecan-8-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thiazole

参考文献

1. Unbekandt M, et al. Cancer Res. 2018 Apr 15;78(8):2096-2114.

BDP8900 (BDP 8900;BDP-8900)

生物&药学活性

物理化学性质&存储条件

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BDP8900 (BDP 8900;BDP-8900)

生物&药学活性

物理化学性质&存储条件

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