BDP5290 | MRCK inhibitor | Probechem Biochemicals

Chemical Structure : BDP5290

CAS No.: 1817698-21-7

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BDP5290 (BDP-5290, BDP 5290, BDP00005290)

货号: PC-63524Not For Human Use, Lab Use Only.

BDP5290 (BDP00005290) is a potent myotonic dystrophy kinase-related CDC42-binding kinase (MRCK) inhibitor with Ki of 10/4 nM for MRCKα/β, respectively.

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5 mg	￥1380	In stock
10 mg	￥2280	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

BDP5290 (BDP00005290) is a potent myotonic dystrophy kinase-related CDC42-binding kinase (MRCK) inhibitor with Ki of 10/4 nM for MRCKα/β, respectively.
BDP5290 exhibits 86 and 46-fold in vitro selectivity for MRCKβ over ROCK1 and ROCK2; demonstrates marked selectivity for MRCKβ over ROCK1 or ROCK2 for inhibition of myosin II light chain (MLC) phosphorylation in cells;.
BDP5290 blocks MLC phosphorylation at both cytoplasmic actin stress fibres and peripheral cortical actin bundles.
BDP5290 strongly inhibits the invasion of human SCC12 squamous cell carcinoma cells at 2 uM.

物理化学性质&存储条件

分子量	371.829
分子式	C17H18ClN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-1-(4-piperidyl)-N-[5-(2-pyridyl)-1H-pyrazol-4-yl]pyrazole-3-carboxamide

参考文献

1. Unbekandt M, et al. Cell Commun Signal. 2014 Oct 5;12:54.

2. Unbekandt M, et al. Cancer Res. 2018 Apr 15;78(8):2096-2114.

BDP5290 (BDP-5290, BDP 5290, BDP00005290)

生物&药学活性

物理化学性质&存储条件

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BDP5290 (BDP-5290, BDP 5290, BDP00005290)

生物&药学活性

物理化学性质&存储条件

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