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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aminopeptidase-BDM_76464
BDM_76464

Chemical Structure : BDM_76464

CAS No.:

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BDM_76464 (BDM-76464, BDM76464)

货号: PC-23921Not For Human Use, Lab Use Only.

BDM_76464 is a potent, selective inhibitor of insulin-regulated aminopeptidase IRAP with IC50 of 23 nM, has >25-fold selecive over ERAP1 and ARAP2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BDM_76464 is a potent, selective inhibitor of insulin-regulated aminopeptidase IRAP with IC50 of 23 nM, has >25-fold selecive over ERAP1 and ARAP2. potently decrease production of IL-2 by B3Z hybridoma with IC50 of 2.91 uM.

物理化学性质&存储条件

分子量 423.51
分子式 C24H29N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[2-(5-Benzyloxy-1H-indol-3-yl)ethyl]-2-(hydroxycarbamoyl)-4-methyl-pentanamide

参考文献

1. He B, et al. J Med Chem. 2025 Feb 7. doi: 10.1021/acs.jmedchem.4c01744.

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