BDM91288 | AcrB efflux pump inhibitor | Probechem Biochemicals

Chemical Structure : BDM91288

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BDM91288 (BDM 91288)

货号: PC-21689Not For Human Use, Lab Use Only.

BDM91288 is a pyridylpiperazine-based AcrB efflux pump inhibitor, potentiate the activity of a panel of antibiotics against K. pneumoniae.

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生物&药学活性

BDM91288 is a pyridylpiperazine-based AcrB efflux pump inhibitor, potentiate the activity of a panel of antibiotics against K. pneumoniae.
BDM91288 inhibits the AcrB component of the primary K. pneumoniae efflux pump and allows for broad spectrum antibiotic boosting effect.
BDM91288 reverses resistance in K. pneumoniae mediated by clinically relevant mutations in the transcriptional regulator RamR that confers efflux pump overexpression.
BDM91288 demonstrated to potentiate the activity of the efflux substrate levofloxacin in in vivo murine models of K. pneumoniae lung infection.

物理化学性质&存储条件

分子量	331.85
分子式	C17H22ClN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-chloro-2,6-di(piperazin-1-yl)quinoline

参考文献

1. Anais Vieira Da Cruz, et al. EMBO Mol Med. 2024 Jan;16(1):93-111.

BDM91288 (BDM 91288)

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物理化学性质&存储条件

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BDM91288 (BDM 91288)

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物理化学性质&存储条件

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