BDM88951 | ERAP2 inhibitor | Probechem Biochemicals

Chemical Structure : BDM88951

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BDM88951 (BDM 88951)

货号: PC-49177Not For Human Use, Lab Use Only.

BDM88951 (BDM 88951) is a highly potent, selective inhibitor of endoplasmic reticulum aminopeptidase 2 (ERAP2) with IC50 of 19 nM.

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生物&药学活性

BDM88951 (BDM 88951) is a highly potent, selective inhibitor of endoplasmic reticulum aminopeptidase 2 (ERAP2) with IC50 of 19 nM.
BDM88951 displays selectivity index (>150) towards closely related ERAP1 and IRAP enzymes, as well as MMPs, TACE and LAP3.
BDM88951 is a potent inhibitor of ERAP2-mediated hydrolysis of two nonapeptides precursors of SIINFEKL, an ovalbumine-derived antigen, in a
dose dependent manner.
BDM88951 engage ERAP2 in cells and inhibits antigen presentation in a cellular context, also displays favorable in vitro ADME properties and in vivo exposure.

物理化学性质&存储条件

分子量	513.587
分子式	C23H23N5O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-Hydroxy-3-(4-methoxyphenyl)-2-(4-((5-phenylthiophene-2-sulfonamido)methyl)-1H-1,2,3-triazol-1-yl)propanamide

参考文献

1. Virgyl Camberlein, et al. Angew Chem Int Ed Engl. 2022 Jul 29. doi: 10.1002/anie.202203560.

BDM88951 (BDM 88951)

生物&药学活性

物理化学性质&存储条件

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BDM88951 (BDM 88951)

生物&药学活性

物理化学性质&存储条件

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