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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-BDM88855
BDM88855

Chemical Structure : BDM88855

CAS No.: 2892824-25-6

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BDM88855 (BDM 88855)

货号: PC-72795Not For Human Use, Lab Use Only.

BDM88855 is a novel allosteric efflux-pump inhibitor that potentiate antibiotic activity in E. coli through inhibition of its primary RND transporter, AcrAB-TolC.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BDM88855 is a novel allosteric efflux-pump inhibitor that potentiate antibiotic activity in E. coli through inhibition of its primary RND transporter, AcrAB-TolC.
    BDM88855 binds to a unique site on the transmembrane domain of the AcrB L protomer, lined by key catalytic residues involved in proton relay, boost antibiotic activity in E. coli by inhibiting the AcrAB-TolC efflux pump.

    物理化学性质&存储条件

    分子量 247.726
    分子式 C13H14ClN3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-chloro-2-(piperazin-1-yl)quinoline

    参考文献

    1. Coline Plé, et al. Nat Commun. 2022 Jan 10;13(1):115.

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