BDK inhibitor BT2

Chemical Structure : BDK inhibitor BT2

CAS No.: 34576-94-8

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货号: PC-49378Not For Human Use, Lab Use Only.

BDK inhibitor BT2 is a small molecule allosteric inhibitor of BCKDC kinase (BDK, branched-chain ketoacid dehydrogenase kinase) with IC50 of 3.19 uM.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥2980	In stock
250 mg		Get quote

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生物&药学活性

BDK inhibitor BT2 is a small molecule allosteric inhibitor of BCKDC kinase (BDK, branched-chain ketoacid dehydrogenase kinase) with IC50 of 3.19 uM.
BDK inhibitor BT2 significantly increases BCKDC activity in wild-type and MSUD cells the mitochondrial branched-chain α-ketoacid dehydrogenase complex (BCKDC).
BDK inhibitor BT2 binds to the same site in BDK as other known allosteric BDK inhibitors, including (S)-α-cholorophenylproprionate ((S)-CPP).
Administration of BT2 at 20 mg/kg/day to wild-type mice for 1 week leads to nearly complete dephosphorylation and maximal activation of BCKDC in heart, muscle, kidneys, and liver with reduction in plasma BCAA concentrations.
BT2 treatment reduced steatosis and/or inflammation, improved sulin sensitivity in HFD-fed and lean mice.

物理化学性质&存储条件

分子量	247.089
分子式	C9H4Cl2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,6- dichlorobenzo[b]thiophene-2-carboxylic acid

参考文献

1. Shih-Chia Tso, et al. J Biol Chem. 2014 Jul 25;289(30):20583-93.

2. Bollinger E, et al. Mol Metab. 2022 Oct 8:101611.