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首页-小分子抑制剂&激动剂-Apoptosis-Bcl-2-BDA-366
BDA-366

Chemical Structure : BDA-366

CAS No.: 1909226-00-1

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BDA-366 (NSC-639366;NSC639366;BDA366)

货号: PC-60281Not For Human Use, Lab Use Only.

BDA-366 (NSC639366) is a potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BDA-366 (NSC639366) is a potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM.
BDA-366 (NSC639366) shows no affinity for other Bcl2 family members, including Bcl-XL, Mcl-1, or Bfl-1/A1.
BDA-366 (NSC639366) induces apoptotic cell death in a Bax-dependent manner, and induces calcium (Ca2+) release via inhibition of Bcl2/IP3R interaction; potently represses lung cancer in vivo.
BDA-366 (NSC639366) induces Bcl2 conformational change in tumor tissues.

物理化学性质&存储条件

分子量 423.5
分子式 C24H29N3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(((S)-3-(diethylamino)-2-hydroxypropyl)amino)-4-((((S)-oxiran-2-yl)methyl)amino)anthracene-9,10-dione

参考文献

1. Han B, et al. Cancer Cell. 2015 Jun 8;27(6):852-63.

2. Deng J, et al. Oncotarget. 2016 May 10;7(19):27753-63.

3. Vervloessem T, et al. Aging (Albany NY). 2015 Oct;7(10):748-9.

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