BCX9930 (Pelecopan)

Chemical Structure : BCX9930

CAS No.: 2378380-49-3

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货号: PC-24548Not For Human Use, Lab Use Only.

BCX9930 (Pelecopan) is a potent, selective oral inhibitor of complement Factor D with IC50 of 14.3 nM (purified human factor D), inhibits the activation of the complement alternative pathway (AP).

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥2980	In stock
10 mg	￥4580	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

BCX9930 (Pelecopan) is a potent, selective oral inhibitor of complement Factor D with IC50 of 14.3 nM (purified human factor D), inhibits the activation of the complement alternative pathway (AP).
BCX9930 does not inhibit enzyme activity of the human serine proteases thrombin, activated protein C, tissue plasminogen activator and trypsin up to 28 μM, and activated factor X and activated factor XII up to 50 μM.
BCX9930 also inhibits its proteolytic activity against factor B bound to C3b with a mean IC50 of 28.1 nM.
BCX9930 inhibits AP-mediated hemolysis of rabbit erythrocytes with a mean IC50 of 29.5 nM.
BCX9930 completely suppresses AP-mediated hemolysis with a mean IC50 of 35.4 nM in erythrocytes from paroxysmal nocturnal hemoglobinuria (PNH) patients.
BCX9930 suppresses AP activity of serum measured by AP-dependent generation of C5b-9 in monkeys.

物理化学性质&存储条件

分子量	406.41
分子式	C23H19FN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-((7-(2-(Aminomethyl)-3-fluoropyridin-4-yl)benzofuran-5-yl)methoxy)phenyl)acetic acid

参考文献

1. Xilin Chen MDPhD, et al. Blood, Volume 136, Supplement 1, 5 November 2020, Page 32

2. Davidson M, et al. J Clin Pharmacol. 2025 Apr 28. doi: 10.1002/jcph.70032.