BCX-1470 | Factor D/C1s inhibitor | Probechem Biochemicals

Chemical Structure : BCX-1470

CAS No.: 217099-43-9

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BCX-1470 (BCX 1470, BCX1470)

货号: PC-45881Not For Human Use, Lab Use Only.

BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).
BCX-1470 displays 3.4-fold and 200-fold bette than that of trypsin, respectively.
BCX-1470 inhibits esterolytic activity translates into potent inhibition of the proteolytic activity of C1s, factor D, and consequently of the classical and alternative pathway-mediated hemolysis of target RBC (IC50=46 nM and 330 nM, respectively).
BCX-1470 blocks the reverse passive Arthus (RPA) reaction in rats.

物理化学性质&存储条件

分子量	302.3714
分子式	C14H10N2O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Thiophenecarboxylic acid, 2-(aminoiminomethyl)benzo[b]thiophen-6-yl ester

参考文献

1. Szalai AJ, et al. J Immunol. 2000 Jan 1;164(1):463-8.

2. Babu, Y. S, et al. Patent No. WO 98/55471.

BCX-1470 (BCX 1470, BCX1470)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

BCX-1470 (BCX 1470, BCX1470)

生物&药学活性

物理化学性质&存储条件

参考文献

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