BCL6 inhibitor 79-6 (CID5721353) |CAS:301356-95-6 Probechem Biochemicals

Chemical Structure : BCL6 inhibitor 79-6

CAS No.: 301356-95-6

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BCL6 inhibitor 79-6 (Compound 79-6, CID5721353)

货号: PC-60926Not For Human Use, Lab Use Only.

BCL6 inhibitor 79-6 (Compound 79-6) is the first-generation, specific BCL6 BTB domain inhibitor with IC50 of 200 uM, Kd of 129 uM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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BCL6 inhibitor 79-6 (Compound 79-6, CID5721353) is the first-generation, specific BCL6 BTB domain inhibitor with IC50 of 200 uM, Kd of 129 uM.
BCL6 inhibitor 79-6 binds to a pocket in the lateral groove of the BCL6 BTB domain, specifically inhibits BCL6 but not other BTB-ZF proteins.
BCL6 inhibitor 79-6 disrupts BCL6/corepressor complexes and reactivates BCL6 target genes in vitro and in vivo, selectively kills BCL6-dependent DLBCL cells.
BCL6 inhibitor 79-6 suppresses human DLBCL xenografts in mice with favorable pharmacokinetics.

物理化学性质&存储条件

分子量	457.269
分子式	C15H9BrN2O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-(5-(5-bromo-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)succinic acid

参考文献

1. Cerchietti LC, et al. Cancer Cell. 2010 Apr 13;17(4):400-11.

2. Cardenas MG, et al. J Clin Invest. 2016 Sep 1;126(9):3351-62.

BCL6 inhibitor 79-6 (Compound 79-6, CID5721353)

生物&药学活性

物理化学性质&存储条件

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BCL6 inhibitor 79-6 (Compound 79-6, CID5721353)

生物&药学活性

物理化学性质&存储条件

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