BCL6-IN-8 |CAS:2204272-40-0 Probechem Biochemicals

Chemical Structure : BCL6-IN-8

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BCL6-IN-8 (BCL6-i)

货号: PC-62538Not For Human Use, Lab Use Only.

BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface.

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生物&药学活性

BCL6-IN-8 (BCL6-i) is a potent, irreversible and cell-active BCL6 inhibitor with inact/KI value of 1.9 × 104 M-1 s-1, targets Cys53 located at the protein-protein interaction interface.
BCL6-IN-8 shows intracellular PPI inhibitory activity between BCL6 and its corepressors, thus resulting in BCL6-dependent DLBCL cell growth inhibition.
BCL6-i is a cell-active chemical probe with the most potent BCL6 inhibitory activity reported to date.

物理化学性质&存储条件

分子量	666.553
分子式	C30H37Cl2N5O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(2-(7-((2-chloro-4-nitro-5-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)amino)-2-(4-(2-chloroacetamido)butyl)-3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)ethyl)propionamide

参考文献

1. Sameshima T, et al. Biochemistry. 2018 Feb 7. doi: 10.1021/acs.biochem.7b00732.

BCL6-IN-8 (BCL6-i)

生物&药学活性

物理化学性质&存储条件

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BCL6-IN-8 (BCL6-i)

生物&药学活性

物理化学性质&存储条件

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