BCI-215 | DUSP-MKP inhibitor | Probechem Biochemicals

Chemical Structure : BCI-215

CAS No.: 1245792-67-9

加入收藏

BCI-215 (BCI215, BCI 215)

货号: PC-60691Not For Human Use, Lab Use Only.

BCI-215 (BCI215) is a potent, tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BCI-215 (BCI215) is a potent, tumor cell-selective dual specificity MAPK phosphatase (DUSP-MKP) inhibitor.
BCI-215 restores defective MAPK activity caused by overexpression of DUSP1 and DUSP6 in mammalian cells.
BCI-215 inhibits cell motility, causes apoptosis but not primary necrosis, and sensitizes cells to lymphokine-activated killer cell activity in MDA-MB-231 human breast cancer cells.
BCI-215 induces rapid and sustained phosphorylation of ERK, p38 and JNK, also hyperactivates MKK4/SEK1.
BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling.

物理化学性质&存储条件

分子量	396.328
分子式	C22H22BrNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-benzylidene-5-bromo-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one

参考文献

1. Kaltenmeier CT, et al. J Pharmacol Exp Ther. 2017 Apr;361(1):39-50.

BCI-215 (BCI215, BCI 215)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BCI-215 (BCI215, BCI 215)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.