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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-BCI-121
BCI-121

Chemical Structure : BCI-121

CAS No.: 432529-82-3

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BCI-121 (BCI 121, BCI121)

货号: PC-70108Not For Human Use, Lab Use Only.

BCI-121 (BCI121) is a substrate-competitive SMYD3 inhibitor that significantly inhibits SMYD3-substrate interaction and chromatin recruitment and is effective in reducing proliferation in various cancer cells types.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BCI-121 (BCI121) is a substrate-competitive SMYD3 inhibitor that significantly inhibits SMYD3-substrate interaction and chromatin recruitment and is effective in reducing proliferation in various cancer cells types.
BCI-121 impairs SMYD3-mediated H4 in vitro methylation, reduced proliferation of HT29 and HCT116 cells.
BCI-121 reproduces the effects of SMYD3-targeted RNAi.

物理化学性质&存储条件

分子量 340.22
分子式 C14H18BrN3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(Aminocarbonyl)-N-(4-bromophenyl)-1-piperidineacetamide

参考文献

1. Peserico A, et al. J Cell Physiol. 2015 Oct;230(10):2447-2460.

2. Huang L, et al. Am J Transl Res. 2017 Jan 15;9(1):1-14.

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