BCH001 | PAPD5 inhibitor | Probechem Biochemicals

Chemical Structure : BCH001

CAS No.: 384859-58-9

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BCH001 (BCH-001)

货号: PC-72257Not For Human Use, Lab Use Only.

BCH001 (BCH-001) a specific, small molecule PAPD5 inhibitor, inhibits rPAPD5 in the low micromolar range in vitro.

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10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

BCH001 (BCH-001) a specific, small molecule PAPD5 inhibitor, inhibits rPAPD5 in the low micromolar range in vitro.
BCH001 showed no inhibition of PARN or several other canonical and non-canonical polynucleotide polymerases.
BCH001 exhibited ATP- and dose-dependent binding to rPAPD5.
BCH001 (0.1-1 uM) restores TERC and telomere length in dyskeratosis congenita (DC) patient iPSCs, reversibly normalizes telomere length and non-coding RNA biogenesis.
BCH001 upregulates TERC without immortalizing TERT-negative cells, restores TERC maturation in PARN-deficient primary human HSPCs and leukemia cell lines.

物理化学性质&存储条件

分子量	420.344
分子式	C20H15F3N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-(ethoxycarbonyl)-6-(trifluoromethoxy)quinolin-4-yl)amino)benzoic acid

参考文献

1. Nagpal N, et al. Cell Stem Cell. 2020 Jun 4;26(6):896-909.e8.

BCH001 (BCH-001)

生物&药学活性

物理化学性质&存储条件

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BCH001 (BCH-001)

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