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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-BC54
BC54

Chemical Structure : BC54

CAS No.: 534579-04-9

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BC54 (PDE4/7 inhibitor BC54)

货号: PC-61333Not For Human Use, Lab Use Only.

BC54 is a potent and biologically-active PDE4/7 inhibitor with IC50 of 50-100 nM for PDE4A/B/D, and 140 nM for both PDE7A/B.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BC54 is a potent and biologically-active PDE4/7 inhibitor with IC50 of 50-100 nM for PDE4A/B/D, and 140 nM for both PDE7A/B.
    BC54 showed only modest activity (IC50=3 uM) against PDE2A and PDE11A, and little to no activity (IC50 >10 uM) against PDE1C/3B/5A /8A/9A/10A.
    BC54 displays exceptional anti-inflammatory activity and induces apoptosis in CLL cells.

    物理化学性质&存储条件

    分子量 408.458
    分子式 C22H24N4O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl (Z)-2-(acetylimino)-1-cyclohexyl-5-oxo-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxylate

    参考文献

    1. de Medeiros AS, et al. Cell Signal. 2017 Sep 1;40:73-80.

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