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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-BC1618
BC1618

Chemical Structure : BC1618

CAS No.: 2222094-18-8

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BC1618 (BC-1618)

货号: PC-72478Not For Human Use, Lab Use Only.

BC1618 (BC-1618) a novel inhibitor of orphan ubiquitin E3 ligase subunit protein Fbxo48, interrupts Fbxo48/pAmpkα interaction and increases pAmpkα levels.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BC1618 (BC-1618) a novel inhibitor of orphan ubiquitin E3 ligase subunit protein Fbxo48, interrupts Fbxo48/pAmpkα interaction and increases pAmpkα levels.
BC1618 demonstrated greater potency in stimulating Ampk-dependent signaling than AICAR or metformin.
BC1618 increases the biological activity of Ampk not by stimulating the activation of Ampk, but rather by preventing activated pAmpkα from Fbxo48-mediated degradation.
BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in diet-induced obese mice.

物理化学性质&存储条件

分子量 415.456
分子式 C24H24F3NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(dibenzylamino)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol

参考文献

1. Liu Y, et al. Nat Chem Biol. 2021 Mar;17(3):298-306.

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