BC-N102

Chemical Structure : BC-N102

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货号: PC-72139Not For Human Use, Lab Use Only.

BC-N102 is a first-in-class novel small molecule inhibitor for targeting oncogenic and hormonal signaling in ER-positive breast cancer.

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250 mg		Get quote

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生物&药学活性

BC-N102 is a first-in-class novel small molecule inhibitor for targeting oncogenic and hormonal signaling in ER-positive breast cancer.
BC-N102 exhibits anticancer activity against breast cancer cell lines via interfering with cell cycle regulatory proteins and hormonal receptors signaling in vitro (IC50=0.04-10 uM), no significant activities against a normal breast cell line.
BC-N102 exhibits potent antitumor activity at tolerated doses in an ER+ human xenograft breast cancer model.
BC-N102 induces arrest of the cell cycle at G0/G1 phase, downregulates the expression of CDK2 and CDK4 independent of the ER in breast cancer cell lines.

物理化学性质&存储条件

分子量	340.825
分子式	C18H13ClN2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	10-chloro-6-(ethylamino)-12H-thiochromeno[2,3-c]quinolin-12-one

参考文献

1. Bashir Lawal, et al. Int J Biol Sci. 2021 Jul 25;17(12):3224-3238.

BC-N102

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BC-N102

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物理化学性质&存储条件

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