BC-23 |CAS:6298-15-3 Probechem Biochemicals

Chemical Structure : BC-23

CAS No.: 6298-15-3

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BC-23 (BC23;NSC 45382)

货号: PC-61804Not For Human Use, Lab Use Only.

BC-23 (NSC 45382) is a novel inhibitor of β-catenin/Tcf4 interaction with IC50 of 1.7 uM.

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5 mg	￥1980	In stock
10 mg	￥3280	In stock
25 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

BC-23 (NSC 45382) is a novel inhibitor of β-catenin/Tcf4 interaction with IC50 of 1.7 uM.
BC-23 dose-dependently inhibits TOP-luciferase activity in H1299 cells with IC50 of 2.3 uM.
BC-23 causes strong synergistic enhancement of the cancer cell death induced by low doses of radiation.
BC-23 effectively inhibits Wnt/β-catenin signaling and down-regulates c-Myc and cyclin D1 expression, induces S phase and ROS generation, and overcomes radioresistance in human NSCLC cells.

物理化学性质&存储条件

分子量	439.87
分子式	C21H14ClN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]-N-pyridin-2-ylbenzenesulfonamide

参考文献

1. Zhang Q, et al. PLoS One. 2016 Mar 25;11(3):e0152407.

BC-23 (BC23;NSC 45382)

生物&药学活性

物理化学性质&存储条件

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BC-23 (BC23;NSC 45382)

生物&药学活性

物理化学性质&存储条件

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