BC-1485 |CAS:2035085-19-7 Probechem Biochemicals

Chemical Structure : BC-1485

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BC-1485 (BC1485)

货号: PC-61670Not For Human Use, Lab Use Only.

BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination.

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生物&药学活性

BC-1485 is a first-in-class, small molecule inhibitor of FIEL1 (Fibrosis-inducing E3 ligase 1) that exhibits potent activity toward disrupting FIEL1-directed PIAS4 ubiquitination.
BC-1485 exhibits >100-fold activity in disrupting the FIEL1-PIAS4 interaction compared with BC-1480.
BC-1485 dose-dependently increases PIAS4 protein levels, stabilize PIAS4 in cells.
BC-1485 ameliorates fibrosis in murine models.

物理化学性质&存储条件

分子量	431.467
分子式	C19H21N5O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-(dimethylamino)-1-oxopropan-2-yl)-4-((2-oxo-2,3-dihydro-1H-benzo[d]imidazole)-5-sulfonamido)benzamide

参考文献

1. Lear T, et al. J Exp Med. 2016 May 30;213(6):1029-46.

2. Lear T, et al. Cytokine. 2016 Dec;88:193-195.

BC-1485 (BC1485)

生物&药学活性

物理化学性质&存储条件

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BC-1485 (BC1485)

生物&药学活性

物理化学性质&存储条件

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