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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Deubiquitinase (DUB)-BC-1471
BC-1471

Chemical Structure : BC-1471

CAS No.: 896683-84-4

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BC-1471 (BC1471;BC 1471)

货号: PC-61626Not For Human Use, Lab Use Only.

BC-1471 is a selective, small-molecule deubiquitinase STAM-binding protein (STAMBP) inhibitor (IC50=0.33 uM) that interrupts STAMBP-Ub-NALP7 interaction.

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10 mg ￥3680 In stock
25 mg ￥5780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BC-1471 is a selective, small-molecule deubiquitinase STAM-binding protein (STAMBP) inhibitor (IC50=0.33 uM) that interrupts STAMBP-Ub-NALP7 interaction.
BC-1471 blocks STAMBP mediated deubiquitination of Ub-NALP7 in vitro, decreases endogenous NALP7 abundance in THP-1 cells, but not NALP6, NALP3, ASC or pro-caspase-1.
BC-1471 suppresses IL-1β release in several complementary human inflammatory systems, including THP-1 monocyte/macrophages, PBMCs and lung organ culture.

物理化学性质&存储条件

分子量 508.637
分子式 C27H32N4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-((6-Morpholino-4-oxo-3-phenethyl-3,4-dihydroquinazolin-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide

参考文献

1. Bednash JS, et al. Nat Commun. 2017 May 11;8:15203.

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