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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-BC-1382
BC-1382

Chemical Structure : BC-1382

CAS No.: 1013753-99-5

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BC-1382 (BC 1382; BC1382)

货号: PC-60547Not For Human Use, Lab Use Only.

BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM.

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10 mg ￥3580 In stock
25 mg ￥5680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM.
BC-1382 drastically increases PIAS1 protein level with IC50 of 100 nM and improves PIAS1 protein stability, with no effect on PIAS3, PIAS4, and HECTD2 protein levels.
BC-1382 suppresses LPS-induced PIAS1 degradation and restores PIAS1 protein levels at 800 nM, and proinflammatory cytokines released by PBMCs。
BC-1382 attenuates LPS- and Pseudomonas aeruginosa-induced lung inflammation

物理化学性质&存储条件

分子量 459.561
分子式 C23H29N3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(1-((2-methoxybenzyl)amino)-1-oxopropan-2-yl)-1-(phenylsulfonyl)piperidine-4-carboxamide

参考文献

1. Coon TA, et al. Sci Transl Med. 2015 Jul 8;7(295):295ra109.

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