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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-BC-1215
BC-1215

Chemical Structure : BC-1215

CAS No.: 1507370-20-8

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BC-1215 (BC 1215;BC1215)

货号: PC-60879Not For Human Use, Lab Use Only.

BC-1215 (BC1215) is a highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1β IC50 of 0.9 ug/mL.

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10 mg ￥880 In stock
25 mg ￥1580 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BC-1215 (BC1215) is a potent, highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1β IC50 of 0.9 ug/mL.
BC-1215 inhibits the Fbxo3-TRAF activation pathway for cytokine release, increases immunoreactive Fbxl2 levels and reduces TRAF proteins, impairs Fbxo3 ubiquitination of Fbxl2 with IC50 of 0.1 uM in vitro ubiquitination assay.
BC-1215 reversibly inhibits Fbxo3 to destabilize TRAF proteins, remarkably suppresses the majority of the Th1 panel cytokines including G-CSF, GM-CSF, GROα, I-309, IL1-α, IL1-β, IL1rα, IL-6, IL-12, IL-23, MIP-1α, MIP-1β and TNFα, in PBMCs.
BC-1215 ameliorates the severity of viral pneumonia, septic shock, colitis, and cytokine-driven inflammation systemically in murine models.

物理化学性质&存储条件

分子量 394.522
分子式 C26H26N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N1,N2-bis(4-(pyridin-2-yl)benzyl)ethane-1,2-diamine

参考文献

1. Mallampalli RK, et al. J Immunol. 2013 Nov 15;191(10):5247-55.

2. Lin TB, et al. J Neurosci. 2015 Dec 16;35(50):16545-60.

3. Lai CY, et al. J Neurosci. 2016 Sep 14;36(37):9722-38.

4. Chen BB, et al. Nat Immunol. 2013 May;14(5):470-9.

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