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首页-小分子抑制剂&激动剂-Tyrosine Kinase-RET Tyrosine Kinase (c-RET)-BBT594
BBT594

Chemical Structure : BBT594

CAS No.: 882405-89-2

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BBT594 (NVP-BBT594, BBT-594)

货号: PC-45558Not For Human Use, Lab Use Only.

BBT594 (NVP-BBT594) is a potent RET inhibitor that can impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BBT594 (NVP-BBT594) is a potent RET inhibitor that can impairs GDNF-RET signaling and GDNF-dependent growth of MCF7-LTED cells.
BBT594 significantly enhances the antiproliferative effects of letrozole (SF50=2.9 nM).

物理化学性质&存储条件

分子量 569.5781
分子式 C28H30F3N7O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 33 mg/mL
Chemical Name/SMILES

1H-Indole-1-carboxamide, 5-[[6-(acetylamino)-4-pyrimidinyl]oxy]-2,3-dihydro-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-

参考文献

1. Morandi A, et al. Cancer Res. 2013 Jun 15;73(12):3783-95.

2. Andreucci E, et al. Oncotarget. 2016 Dec 6;7(49):80543-80553.

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