BBI-2779 | CHK1 inhibitor | Probechem Biochemicals

Chemical Structure : BBI-2779

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BBI-2779 (BBI 2779)

货号: PC-23369Not For Human Use, Lab Use Only.

BBI-2779 is a potent, selective and orally bioavailable inhibitor of CHK1 with biochemical IC50 of 0.5 nM and cellular IC50 of 3 nM (pCHK1-S345 activity in HT29 cells), 160-fold selective for CHK1 over CHK2.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

BBI-2779 is a potent, selective and orally bioavailable inhibitor of CHK1 with biochemical IC50 of 0.5 nM and cellular IC50 of 3 nM (pCHK1-S345 activity in HT29 cells), 160-fold selective for CHK1 over CHK2.
BBI-2779 has superior biochemical and selective cell growth inhibition compared to other orally bioavailable CHK1 inhibitors.
BBI-2779 preferentially kills ecDNA-containing tumour cells, exhibits antiproliferation activity in COLO320DM cells with IC50 of 6 nM.
BBI-2779 suppresses tumour growth and prevents ecDNA-mediated acquired resistance to the pan-FGFR inhibitor infigratinib in gastric cancer model containing FGFR2 amplified on ecDNA, resulting in potent and sustained tumour regression in mice.

物理化学性质&存储条件

分子量	377.41
分子式	C19H19N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-(2-((1R,2R)-2-aminocyclobutoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile

参考文献

1. Tang J, et al. Nature. 2024 Nov;635(8037):210-218.

BBI-2779 (BBI 2779)

生物&药学活性

物理化学性质&存储条件

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BBI-2779 (BBI 2779)

生物&药学活性

物理化学性质&存储条件

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