BBC1115 | BET inhibitor | Probechem Biochemicals

Chemical Structure : BBC1115

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BBC1115 (BBC 1115)

货号: PC-20838Not For Human Use, Lab Use Only.

BBC1115 is a novel chemotype inhibitor of bromodomain and extra-terminal motif (BET) proteins, displays broad binding across BDs of BET proteins.

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生物&药学活性

BBC1115 is a novel chemotype inhibitor of bromodomain and extra-terminal motif (BET) proteins, displays broad binding across BDs of BET proteins.
BBC1115 is structurally distinct from known BET inhibitors.
BBC1115 treatment resulted in a typical response to BET inhibitors, represented by suppression of MYC programs and dissociation of BRD4 from chromatin.
BBC1115 suppresses BET-dependent gene expression programs and exhibits anti-proliferative activity in vitro and in vivo.

物理化学性质&存储条件

分子量	539.60
分子式	C28H27F2N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=CC2=C(OC)C=CC(C(C=C3)=CN(C)C3=O)=C2S1)N(CC4=CC=C(C(F)F)C=C4)CCC(NC)=O

参考文献

1. Seoyeon Jeong, et al. Mol Ther Nucleic Acids. 2023 Apr 24;32:637-649.

BBC1115 (BBC 1115)

生物&药学活性

物理化学性质&存储条件

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BBC1115 (BBC 1115)

生物&药学活性

物理化学性质&存储条件

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