BBC0403 | BRD2 inhibitor | Probechem Biochemicals

Chemical Structure : BBC0403

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BBC0403 (BBC-0403)

货号: PC-22158Not For Human Use, Lab Use Only.

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生物&药学活性

BBC0403 (BBC-0403) is a specific BRD2 inhibitor with binding Kd of 41.4 uM and 7.6 uM for BRD2 (BD1) and BRD2 (BD2), inhibits the NF-κB and MAPK signalling pathways and the progression of osteoarthritis pathogenesis.
BBC0403 displays no affinity for BRD3 (BD1), BRD4 (BD1) and BRD4 (BD2), (Kd>1000 uM).
BBC0403 decreases catabolic factors in osteoarthritis (OA) mimic condition and inhibited extracellular matrix (ECM) degradation.
BBC0403 decreases IL-1β-induced expression of catabolic factors in mouse primary chondrocytes.
BBC0403 (5 and 10 ug/kg, i.a. injection, once a week for 7 weeks) inhibits DMM surgery-induced expression of catabolic factors, preventing cartilage degradation in DMM-induced OA model.
The anti-OA effect of BBC0403 is associated with inhibiting NF-κB and MAPK signalling activated by IL-1β.

物理化学性质&存储条件

分子量	382.42
分子式	C21H22N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,5-dimethyl-4-(oxetan-3-yloxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

参考文献

1. Hyemi Lee, et al. Br J Pharmacol. 2024 Apr 10. doi: 10.1111/bph.16359.

BBC0403 (BBC-0403)

生物&药学活性

物理化学性质&存储条件

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BBC0403 (BBC-0403)

生物&药学活性

物理化学性质&存储条件

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