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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-BB2-50F
BB2-50F

Chemical Structure : BB2-50F

CAS No.: 2226086-65-1

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BB2-50F (BB 2-50F)

货号: PC-21654Not For Human Use, Lab Use Only.

BB2-50F is a bactericidal inhibitor of M. tuberculosis with MIC value of 8 uM (H37Rv), inhibits succinate dehydrogenase and the F1Fo-ATP synthase.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BB2-50F is a bactericidal inhibitor of M. tuberculosis with MIC value of 8 uM (H37Rv), inhibits succinate dehydrogenase (SDH) and the F1Fo-ATP synthase.
BB2-50F inhibits the growth of M. tuberculosis H37Rv and the BSL2 approved H37Rv auxotrophic-attenuated derivative mc2 6230 (ΔRD1, ΔpanCD) with MIC of 8 uM.
BB2-50F inhibits the growth of a panel of 22 M tuberculosis mc2 6206 (ΔleuD, ΔpanCD) mono-resistant mutants isolated against a variety of TB drugs including isoniazid (INH), rifampicin (RIF), BDQ, and PA-824 with a similar MIC as wild-type (WT).
BB2-50F (10X MIC) kills replicating cultures of M. tuberculosis mc2 6230 more rapidly than the current TB drugs BDQ, INH, and RIF.
BB2-50F potentiates the killing of M. tuberculosis by first- and second-line TB antibiotics.
BB2-50F inhibits mycobacterial succinate oxidation, dysregulates the TCA cycle and secretion of TCA cycle metabolites to prevent their intracellular toxicity.

物理化学性质&存储条件

分子量 393.45
分子式 C20H23N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-amino-5-(azepan-1-yl)-6-(benzofuran-2-yl)-N-carbamimidoylpyrazine-2-carboxamide

参考文献

1. Cara Adolph, et al. Cell Chem Biol. 2023 Dec 21:S2451-9456(23)00432-4.

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