Chemical Structure : BAY885
CAS No.: 2307249-33-6
货号: PC-35332Not For Human Use, Lab Use Only.
BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM, shows high selectivity over a panel of 357 kinases (Eurofins panel).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥2380 | In stock | |
10 mg | ¥3780 | In stock | |
25 mg | ¥5780 | In stock | |
50 mg | Get quote | ||
100 mg | Get quote |
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BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM, shows high selectivity over a panel of 357 kinases (Eurofins panel).
BAY-885 strongly inhibits EGF-stimulated MEF2 transcriptional activity in MEF2 reporter assay with IC50 of 115 nM.
Despite its high potency, BAY-885 failed to inhibit the proliferation of cells with ERK5 genomic amplification (SN12C, SNU-449, MFM-223) or with constitutively active ERK5 signaling (BT-474, SK-BR-3).
分子量 | 515.541 | |
分子式 | C25H28F3N7O2 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(2-amino-4-(trifluoromethoxy)phenyl)(4-(7-(4-methylpiperazin-1-yl)pyrido[3,2-d]pyrimidin-4-yl)piperidin-1-yl)methanone |
1. Clara Lemos, et al. Abstract 5866: Discovery and profiling of a highly potent and selective ERK5 inhibitor: BAY-885. AACR. 2018.
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