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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-BAY 73-6691
BAY 73-6691

Chemical Structure : BAY 73-6691

CAS No.: 794568-92-6

BAY 73-6691 (BAY 736691;BAY736691)

货号: PC-61334Not For Human Use, Lab Use Only.

BAY 73-6691 is a potent and selective PDE9 inhibitor with IC50 of 55 nM and 100 nM for human and murine PDE9, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    BAY 73-6691 is a potent and selective PDE9 inhibitor with IC50 of 55 nM and 100 nM for human and murine PDE9, respectively.
    BAY 73-6691 shows only moderate activity against other cyclic nucleotide-specific PDEs.
    BAY 73-6691 induces concentration-dependent intracellular cGMP accumulation combined with sGC activator BAY 58-2667 or BAY 41-2272.
    BAY 73-6691 attenuates the scoplamine-induced retention deficit and the MK-801-induced short-term memory deficits, improves learning and memory in rodents.

    物理化学性质&存储条件

    分子量 356.73
    分子式 C15H12ClF3N4O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    1-(2-Chlorophenyl)-1,5-dihydro-6-[(2R)-3,3,3-trifluoro-2-methylpropyl]-4H-pyrazolo[3,4-d]pyrimidin-4-one

    参考文献

    1. Wunder F, et al. Mol Pharmacol. 2005 Dec;68(6):1775-81.

    2. van der Staay FJ, et al. Neuropharmacology. 2008 Oct;55(5):908-18.

    3. Almeida CB, et al. Br J Haematol. 2008 Sep;142(5):836-44.

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