BAY 61-3606 dihydrochloride
(BAY61-3606 dihydrochloride;BAY 61-3606)
货号: PC-44143Not For Human Use, Lab Use Only.
BAY 61-3606 dihydrochloride is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase with Ki of 7.5 nM, displays no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
BAY 61-3606 dihydrochloride is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase with Ki of 7.5 nM, displays no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
BAY 61-3606 inhibits not only degranulation (IC50=5-46 nM) but also lipid mediator and cytokine synthesis in mast cells.
BAY 61-3606 suppresses B cell receptor activation and receptors for Fc portion of IgG signaling in eosinophils and monocytes.
BAY 61-3606 suppresses antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema at 3 mg/kg in rats; orally bioavailable.
