BAY 60-7550 | PDE2 inhibitor | Probechem Biochemicals

Chemical Structure : BAY 60-7550

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BAY 60-7550 (Bay60-7550)

货号: PC-22039Not For Human Use, Lab Use Only.

BAY 60-7550 (Bay60-7550) is a potent and selective PDE2 inhibitor with Ki of 3.8 nM, IC50 of 4.7 nM (human PDE2A), and 2.0 nM (bovine purified PDE2).

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生物&药学活性

BAY 60-7550 (Bay60-7550) is a potent and selective PDE2 inhibitor with Ki of 3.8 nM, IC50 of 4.7 nM (human PDE2A), and 2.0 nM (bovine purified PDE2).
BAY 60-7550 displays 50-fold selectivity over PDE1, and 100-800-fold over other PDEs.
BAY 60-7550 enhances long-term potentiation of synaptic transmission without altering basal synaptic transmission in cultured neurons and hippocampal slices.
BAY 60-7550 improves the performance of rats in social and object recognition memory tasks, and reversed MK801-induced deficits in spontaneous alternation in mice in a T-maze.

物理化学性质&存储条件

分子量	476.58
分子式	C27H32N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,4-dimethoxybenzyl)-7-{(1R)-1-[(1R)-1-hydroxyethyl]-4-phenylbutyl}-5-methyl imidazo[5,1-f][1,2,4]triazin-4(3H)-one

参考文献

1. Boess FG, et al. Neuropharmacology. 2004 Dec;47(7):1081-92.

2. Castro LR, et al. Circulation. 2006 May 9;113(18):2221-8.

BAY 60-7550 (Bay60-7550)

生物&药学活性

物理化学性质&存储条件

参考文献

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BAY 60-7550 (Bay60-7550)

生物&药学活性

物理化学性质&存储条件

参考文献

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