BAY 60-6583 | A2BR agonist | Probechem Biochemicals

Chemical Structure : BAY 60-6583

CAS No.: 910487-58-0

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BAY 60-6583 (BAY606583)

货号: PC-35002Not For Human Use, Lab Use Only.

BAY 60-6583 (BAY606583) is a potent, selective adenosine A2B receptor agonist with EC50 of 2.83 nM (murine A2BR).

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2680	In stock
50 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

BAY 60-6583 (BAY606583) is a potent, selective adenosine A2B receptor agonist with EC50 of 2.83 nM (murine A2BR).
BAY 60-6583 inhibits fMLP-stimulated superoxide production by either naive neutrophils,TNF-α-primed neutrophils, or neutrophils isolated from mice at 1-10 nM.
BAY 60-6583 increases fMLP-stimulated superoxide production at higher concentrations (>1 uM)。
BAY 60-6583 exhibits cardioprotective activity, attenuates infarct size in mouse model of myocardial ischemia.

物理化学性质&存储条件

分子量	379.438
分子式	C19H17N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[6-Amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]acetamide

参考文献

1. van der Hoeven D, et al. J Pharmacol Exp Ther. 2011 Sep;338(3):1004-12.

2. Eckle T, et al. Circulation. 2007 Mar 27;115(12):1581-90.

3. Teng B, et al. J Mol Cell Cardiol. 2008 May;44(5):905-14.

BAY 60-6583 (BAY606583)

生物&药学活性

物理化学性质&存储条件

参考文献

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BAY 60-6583 (BAY606583)

生物&药学活性

物理化学性质&存储条件

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