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首页-小分子抑制剂&激动剂-GPCR-Vasoactive intestinal peptide receptor (VIPR)-BAY 55-9837
BAY 55-9837

Chemical Structure : BAY 55-9837

CAS No.: 463930-25-8

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BAY 55-9837 (BAY55-9837)

货号: PC-20661Not For Human Use, Lab Use Only.

BAY 55-9837 is a potent, highly selective peptide agonist of vasoactive intestinal peptide receptor 2 (VIPR2, VPAC2 receptor) with Kd of 0.65 nM, >100-fold selectivity over VPAC1.

规格 价格 库存 数量
1 mg ￥2980 In stock
5 mg ￥4980 In stock
10 mg ￥7980 In stock
25 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BAY 55-9837 is a potent, highly selective peptide agonist of vasoactive intestinal peptide receptor 2 (VIPR2, VPAC2 receptor) with Kd of 0.65 nM, >100-fold selectivity over VPAC1.
BAY 55-9837 stimulated glucose-dependent insulin secretion in isolated rat and human pancreatic islets, increased insulin synthesis in purified rat islets, and caused a dose-dependent increase in plasma insulin levels in fasted rats (EC50=3 pM/kg).
Bay 55-9837 reduced the glucose area under the curve following an intraperitoneal glucose tolerance test.
Bay 55-9837 increases neuronal damage and hemorrhagic transformation after stroke in type 2 diabetic rats.

物理化学性质&存储条件

分子量 3342.20
分子式 C148H239ClN44O42
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Peptide HSDAVFTDNYTRLRKQVAAKKYLQSIKNKRY

参考文献

1. Tsutsumi M, et al. Diabetes. 2002 May;51(5):1453-60.

2. Hadwen J, et al. Orphanet J Rare Dis. 2014 Jan 9;9:4.

3. Darsalia V, et al. Neuropeptides. 2013 Apr;47(2):133-7.

4. Pan CQ, et al. J Pharmacol Exp Ther. 2007 Feb;320(2):900-6.

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