BAY 41-2272 |CAS:256376-24-6 Probechem Biochemicals

Chemical Structure : BAY 41-2272

CAS No.: 256376-24-6

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BAY 41-2272 (BAY 412272;BAY41-2272)

货号: PC-43008Not For Human Use, Lab Use Only.

BAY 41-2272 is a potent, NO-independent, orally available soluble guanylate cyclase (sGC) stimulator with IC50 of 0.3 uM (relaxation of preconstricted aortic rings).

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

BAY 41-2272 is a potent, NO-independent, orally available soluble guanylate cyclase (sGC) stimulator with IC50 of 0.3 uM (relaxation of preconstricted aortic rings).
BAY 41-2272 targets the cysteine 238 and cysteine 243 region in the alpha1-subunit of sGC, sensitizes sGC to its physiological stimulator nitric oxide.
BAY 41-2272 potently unloads the heart, increases cardiac output, and preserves glomerular filtration rate without activation of the renin-angiotensin-aldosterone system in experimental congestive heart failure models.

物理化学性质&存储条件

分子量	360.3876
分子式	C20H17FN6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 17.5 mg/mL
Chemical Name/SMILES	4-Pyrimidinamine, 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-

参考文献

1. Baracat JS, et al. Eur J Pharmacol. 2003 Sep 12;477(2):163-9.

2. Boerrigter G, et al. Circulation. 2003 Feb 11;107(5):686-9.

3. Stasch JP, et al. Nature. 2001 Mar 8;410(6825):212-5.

4. Straub A, et al. Bioorg Med Chem Lett. 2001 Mar 26;11(6):781-4.

BAY 41-2272 (BAY 412272;BAY41-2272)

生物&药学活性

物理化学性质&存储条件

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BAY 41-2272 (BAY 412272;BAY41-2272)

生物&药学活性

物理化学性质&存储条件

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