BAY3389934 hydrochloride

Chemical Structure : BAY3389934 hydrochloride

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货号: PC-24848Not For Human Use, Lab Use Only.

BAY3389934 hydrochloride is a potent and highly selective, direct dual FIIa/Xa inhibitor with IC50 of 4.9/0.66 nM (in buffer) and 22/9.2 nM (in plasma) respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BAY3389934 hydrochloride is a potent and highly selective, direct dual FIIa/Xa inhibitor with IC50 of 4.9/0.66 nM (in buffer) and 22/9.2 nM (in plasma) respectively.
BAY3389934 hydrochloride has IC50 values of 31 and 5.3 nM (FIIa/FXa) for rabbit and 26 and 16 nM (FIIa/FXa) for minipig plasma.
BAY3389934 hydrochloride has EC200 values of 0.32 μM (PT) and 0.22 μM (aPTT) for in vitro anticoagulant activity.
BAY3389934 hydrochloride (0.23 μM) doubled the CT value in the ROTEM (EXTEM) whole blood assay.
BAY3389934 hydrochloride inhibits pre-existing thrombin by potent inhibition of TF-triggered ongoing, normalizes LPS-induced CT in human whole blood at 130 nM.
BAY3389934 hydrochloride strongly reduced the hypercoagulatory state and protected from organ damage in a baboon model of Staphylococcus aureus sepsis.
BAY3389934 hydrochloride showed high selectivity within the serine protease target family (Table 7), no significant off-target effects on a broad range of targets, including GPCRs, ion channels, nuclear hormone receptors, and other proteins and enzymes (>70 targets).

物理化学性质&存储条件

分子量	660.58
分子式	C26H31Cl2N5O7S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-Methyl-1H-imidazol-2-yl)ethyl 3-[(5-chlorothiophene-2-carbonyl)amino]-N-{2-ethyl-3-[(3S)-3-hydroxy-2-oxopyrrolidin-1-yl]benzene-1-sulfonyl}-S-alaninate hydrochloride

参考文献

1. Beck H, et al. J Med Chem. 2025 Jun 11. doi: 10.1021/acs.jmedchem.5c00538.