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首页-小分子抑制剂&激动剂-GPCR-Vasoactive intestinal peptide receptor (VIPR)-BAY 2686013
BAY 2686013

Chemical Structure : BAY 2686013

CAS No.:

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BAY 2686013 (BAY2686013)

货号: PC-20945Not For Human Use, Lab Use Only.

BAY 2686013 is a selective, allosteric antagonist of human pituitary adenylate cyclase activating polypeptide receptor (hPAC1-R) with IC50 of 0.92 and 0.4 uM in cAMP HTRF and Ca2+ release assays, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

BAY 2686013 is a selective, allosteric antagonist of human pituitary adenylate cyclase activating polypeptide receptor (hPAC1-R) with IC50 of 0.92 and 0.4 uM in cAMP HTRF and Ca2+ release assays, respectively.
BAY 2686013 is a valuable tool compound for better understanding the signalling and function of hPAC1-R.

物理化学性质&存储条件

分子量 392.30
分子式 C17H14F6N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(NC1=CC=C(OCC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C=C1)CN

参考文献

1. Gernot Langer, et al. Mol Pharmacol. 2023 Jun 22;MOLPHARM-AR-2022-000662.

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