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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-BAY 249716
BAY 249716

Chemical Structure : BAY 249716

CAS No.: 696628-24-7

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BAY 249716 (BAY249716)

货号: PC-49087Not For Human Use, Lab Use Only.

BAY 249716 is a small molecule that modulate mutant p53 condensation, showed significant stabilization of all three p53 protein variants, p53WT p53R175H and p53Y220C.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BAY 249716 is a small molecule that modulate mutant p53 condensation, showed significant stabilization of all three p53 protein variants, p53WT p53R175H and p53Y220C.
BAY 249716 exhibits anti-proliferative activity in a set of cell lines with different p53 mutation status with low-uM IC50 values.

物理化学性质&存储条件

分子量 288.753
分子式 C13H9ClN4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(5-chloropyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine

参考文献

1. Clara Lemos, et al. iScience. 2020 Sep 25; 23(9): 101517.

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