BAY 2476568 (BAY-598) | EGFR Ex20Ins inhibitor | Probechem Biochemicals

Chemical Structure : BAY 2476568

CAS No.: 2311901-93-4

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BAY 2476568 (BAY-568)

货号: PC-23314Not For Human Use, Lab Use Only.

BAY 2476568 (BAY-598) is the first reversible, potent and selective inhibitor of EGFR exon 20 insertions with IC50 of 20 and 24 nM for V769_D770insASV (insASV) and D770_N771insSVD (insSVD), with a wide margin of selectivity versus WT EGFR.

规格	价格	库存
5 mg	￥2880	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
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100 mg		Get quote

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生物&药学活性

BAY 2476568 (BAY-598) is the first reversible, potent and selective inhibitor of EGFR exon 20 insertions with IC50 of 20 and 24 nM for V769_D770insASV (insASV) and D770_N771insSVD (insSVD), with a wide margin of selectivity versus WT EGFR.
BAY 2476568 (BAY-598) exhibits greater than 20-fold selectivity for EGFR exon 20 insertions compared to wild-type EGFR in isogenic Ba/F3 models and in cancer cell lines endogenously expressing EGFR exon 20 insertions.
BAY 2476568 (BAY-598) demonstrates the ability of BAY-568 to kill cancer cells harboring exon 20 insertions and other EGFR mutations with decreased activity on wild-type EGFR, irrespective of C797S mutation status.

物理化学性质&存储条件

分子量	454.50
分子式	C24H27FN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(3-Fluoro-2-methoxyphenyl)amino]-1,5,6,7-tetrahydro-2-[3-(2-methoxy-2-methylpropoxy)-4-pyridinyl]-4H-pyrrolo[3,2-c]pyridin-4-one

参考文献

1. Patent WO2019081486A1.

2. F. Siegel et al. Cancer Res. 81, 1470–1470 (2021).

3. Hanchen Zhao, et al. Proc Natl Acad Sci U S A. 2024 Nov 5;121(45):e2417144121.

BAY 2476568 (BAY-568)

生物&药学活性

物理化学性质&存储条件

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BAY 2476568 (BAY-568)

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