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首页-小分子抑制剂&激动剂-Apoptosis-MDM2-p53-BAY 1892005
BAY 1892005

Chemical Structure : BAY 1892005

CAS No.: 2036352-13-1

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BAY 1892005 (BAY1892005)

货号: PC-49086Not For Human Use, Lab Use Only.

BAY 1892005 is a small molecule that modulate mutant p53 condensation and nuclear accumulation, binds covalently to mutant p53R175H and p53Y220C and shows stabilization of p53WT and p53Y220C, exhibits anti-proliferative activity in a set of cell lines with different p53 mutation status with low-uM IC50 values.

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5 mg ￥2180 In stock
10 mg ￥3580 In stock
25 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BAY 1892005 is a small molecule that modulate mutant p53 condensation and nuclear accumulation, binds covalently to mutant p53R175H and p53Y220C and shows stabilization of p53WT and p53Y220C。
BAY 1892005 exhibits anti-proliferative activity in a set of cell lines with different p53 mutation status with low-uM IC50 values.

物理化学性质&存储条件

分子量 270.706
分子式 C11H8ClFN2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-chloro-N-(4-(2-fluorophenyl)thiazol-2-yl)acetamide

参考文献

1. Clara Lemos, et al. iScience. 2020 Sep 25; 23(9): 101517.

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