BAY1238097 |CAS:1564268-08-1 Probechem Biochemicals

Chemical Structure : BAY1238097

CAS No.: 1564268-08-1

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BAY1238097 (BAY 1238097, BAY-1238097)

货号: PC-62283Not For Human Use, Lab Use Only.

BAY 1238097 is a novel BET bromodomain inhibitor with IC50 of 50 nM, inhibits the interaction between BRD4, BRD3 or BRD2 and H4 with IC50 values of 63 nM, 609 nM and 2430 nM in the NanoBRET assay.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3880	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

BAY1238097 is a novel BET bromodomain inhibitor with IC50 of 50 nM, inhibits the interaction between BRD4, BRD3 or BRD2 and H4 with IC50 values of 63 nM, 609 nM and 2430 nM in the NanoBRET assay.
BAY1238097 shows selectivity of the compound for BRD4.
BAY1238097 strongly reduces c-Myc transcript and protein levels in MOLM-13 (AML) and MOLP-8 (MM) cell lines.
BAY1238097 exhibits strong efficacy in the AML models THP-1, MOLM-13 and KG-1.

物理化学性质&存储条件

分子量	451.571
分子式	C25H33N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-7,8-dimethoxy-N,4-dimethyl-1-(4-(4-methylpiperazin-1-yl)phenyl)-4,5-dihydro-3H-benzo[d][1,2]diazepine-3-carboxamide

参考文献

1. Bernasconi E, et al. Br J Haematol. 2017 Jun 27. doi: 10.1111/bjh.14803.

2. Patent WO2014026997A1.

BAY1238097 (BAY 1238097, BAY-1238097)

生物&药学活性

物理化学性质&存储条件

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BAY1238097 (BAY 1238097, BAY-1238097)

生物&药学活性

物理化学性质&存储条件

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