BAY1217389 | MPS1/TTK inhibitor | Probechem Biochemicals

Chemical Structure : BAY1217389

CAS No.: 1554458-53-5

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BAY1217389 (BAY 1217389, BAY-1217389)

货号: PC-43262Not For Human Use, Lab Use Only.

BAY1217389 (BAY-1217389) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.63 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

BAY1217389 (BAY-1217389) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.63 nM.
BAY1217389 shows excellent kinase selectivity in DiscoveRx kinase panel (395 kinases), with exception of PDGFRβ (<10 nM), Kit (10-100 nM).
BAY1217389 abrogates nocodazole-induced metaphase arrest in HeLa cells with IC50 of 0.11 nM, inhibits the proliferation of a panel tumor cell lines covering various cancer with IC50 of 3-300 nM.
BAY1217389 enhances the efficacy of antimitotic cancer drugs and shows potentially overcome resistance in vivo.

物理化学性质&存储条件

分子量	561.5032
分子式	C27H24F5N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	Benzamide, N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl-

参考文献

1. Wengner AM, et al. Mol Cancer Ther. 2016 Apr;15(4):583-92.

BAY1217389 (BAY 1217389, BAY-1217389)

生物&药学活性

物理化学性质&存储条件

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BAY1217389 (BAY 1217389, BAY-1217389)

生物&药学活性

物理化学性质&存储条件

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