BAY1214784 | GnRH-R antagonist | Probechem Biochemicals

Chemical Structure : BAY1214784

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BAY1214784 (BAY-784 )

货号: PC-38730Not For Human Use, Lab Use Only.

BAY 1214784 (BAY-784) is an orally available, potent, and selective antagonist of gonadotropin-releasing hormone receptor (GnRH-R) with IC50 of 21/ 24/ 35 nM for human/rat/cynomolgus GnRH-R, respectively.

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100 mg		Get quote

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生物&药学活性

BAY 1214784 (BAY-784) is an orally available, potent, and selective antagonist of gonadotropin-releasing hormone receptor (GnRH-R) with IC50 of 21/ 24/ 35 nM for human/rat/cynomolgus GnRH-R, respectively.
BAY 1214784 showed no agonistic activity in the human GnRH-R up to 20 uM, and was inactive in a cell-based panel of 25 GPCRs.
BAY 1214784 (10 and 30 mg/kg, p.o.) demonstrated suppression of plasma luteinizing hormone levels in OVX rats and ORX cynomolgus monkeys.

物理化学性质&存储条件

分子量	672.11
分子式	C29H26ClF4N3O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[3H-indole-3,4′-[4H]thiopyran]-5-carboxamide, N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-2-cyclopropyl-1-[(4-fluorophenyl)sulfonyl]-1,2,2′,3′,5′,6′-hexahydro-, 1′,1′-dioxide, (2S)-

参考文献

1. Panknin O, et al. J Med Chem. 2020 Oct 22;63(20):11854-11881.

BAY1214784 (BAY-784 )

生物&药学活性

物理化学性质&存储条件

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BAY1214784 (BAY-784 )

生物&药学活性

物理化学性质&存储条件

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