BAY 1143269 | MNK1 inhibitor | Probechem Biochemicals

Chemical Structure : BAY 1143269

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BAY 1143269 (BAY1143269)

货号: PC-62896Not For Human Use, Lab Use Only.

BAY 1143269 is a potent, selective, orally bioavailable inhibitor of MNK1 with enzyme IC50 of 40 nM at 2 mM ATP.

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生物&药学活性

BAY 1143269 is a potent, selective, orally bioavailable inhibitor of MNK1 with enzyme IC50 of 40 nM at 2 mM ATP.
BAY 1143269 shows considerable activity against MNK2 (IC50=904 nM), similar binding potency to only 4 out of 395 kinases, including PIM1 (IC50=518 nM).
BAY 1143269 strongly regulates downstream factors involved in cell cycle regulation, apoptosis, immune response and epithelial-mesenchymal transition in vitro or in vivo.
BAY 1143269 demonstrates strong efficacy in patient-derived NSCLC xenograft models.

物理化学性质&存储条件

分子量	308.341
分子式	C17H16N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-2-[[3-(2-Benzofuranyl)imidazo[1,2-b]pyridazin-6-yl]oxy]-1-propanamine

参考文献

1. Santag S, et al. Cancer Lett. 2017 Apr 1;390:21-29.

2. Dreas A, et al. Curr Med Chem. 2017;24(28):3025-3053.

BAY 1143269 (BAY1143269)

生物&药学活性

物理化学性质&存储条件

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BAY 1143269 (BAY1143269)

生物&药学活性

物理化学性质&存储条件

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