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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Aldose Reductase-BAY1128688
BAY1128688

Chemical Structure : BAY1128688

CAS No.: 1428988-21-9

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BAY1128688 (BAY-1128688)

货号: PC-20086Not For Human Use, Lab Use Only.

BAY1128688 is a potent, selective steroidal aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 1.4 nM (human AKR1C3).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BAY1128688 is a potent, selective steroidal aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 1.4 nM (human AKR1C3).
BAY1128688 shows no inhibition of AKR1C1, AKR1C2, and AKR1C4 at concentrations up to 10 uM.

物理化学性质&存储条件

分子量 462.57
分子式 C28H31FN2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((8S,9S,13S,14S)-17-(5-fluoropyridin-3-yl)-N,13-dimethyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthrene-3-carboxamido)propanoic acid

参考文献

1. Rižner TL, et al. Pharmacol Res. 2020 Feb;152:104446.

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