BAY 11-7085 |CAS:196309-76-9 Probechem Biochemicals

Chemical Structure : BAY 11-7085

CAS No.: 196309-76-9

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BAY 11-7085 (BAY11-7085;BAY-11-7085;BAY 11-7083)

货号: PC-42493Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

BAY 11-7085 is an inhibitor of the expression of ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50=5-10 uM), acts by selectively inhibiting TNFα-induced phosphorylation of IκB-α without affecting the constitutive IκB-α phosphorylation.
BAY 11-7085 prevents PMA-induced NF-kappaB nuclear translocation.
BAY 11-7085 reduces swelling in both the rat carrageenan paw edema assay and in a rat adjuvant arthritis model.

物理化学性质&存储条件

分子量	249.3287
分子式	C13H15NO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 26 mg/mL
Chemical Name/SMILES	2-Propenenitrile, 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-, (2E)-

参考文献

1. Pierce JW, et al. J Biol Chem. 1997 Aug 22;272(34):21096-103.

2. Hu X, et al. Cancer Res. 2001 Aug 15;61(16):6290-6.

3. Vielma SA, et al. Circ Res. 2003 May 30;92(10):1130-7.

BAY 11-7085 (BAY11-7085;BAY-11-7085;BAY 11-7083)

生物&药学活性

物理化学性质&存储条件

参考文献

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BAY 11-7085 (BAY11-7085;BAY-11-7085;BAY 11-7083)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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