BAY-958 |CAS:1335490-39-5 Probechem Biochemicals

Chemical Structure : BAY-958

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BAY-958 (BAY 958;BAY958;LDC526)

货号: PC-60539Not For Human Use, Lab Use Only.

BAY-958 (BAY958, LDC526) is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1.

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1 g		Get quote

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生物&药学活性

BAY-958 (BAY958, LDC526) is a potent, selective PTEFb/CDK9 inhibitor with IC50 of 5 nM against CDK9/CyclinT1.
BAY-958 displays 52/82/291/>900/>900-fold selectivity compared to CDK2/1/4/6/7.
BAY-958 exhibits good antiproliferative activity in vitro, for example against HeLa cells (IC50=1000 nM) and MOLM-13 cells (IC50=280 nM).
BAY-958 displays efficient cytotoxic activity against CLL cells in vitro, decreases CLL MCL-1 protein levels and triggers apoptosis rather than inhibiting proliferation.
BAY-958 decreases splenic human CLL numbers in xenografted NSG mice, shows significant CLL cell cytotoxicity in TCL1 transgenic mice.

物理化学性质&存储条件

分子量	389.405
分子式	C17H16FN5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-((4-(4-fluoro-2-methoxyphenyl)-1,3,5-triazin-2-yl)amino)phenyl)methanesulfonamide

参考文献

1. Lücking U, et al. ChemMedChem. 2017 Nov 8;12(21):1776-1793.

2. Göthert JR, et al. Oncotarget. 2018 May 29;9(41):26353-26369.

BAY-958 (BAY 958;BAY958;LDC526)

生物&药学活性

物理化学性质&存储条件

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BAY-958 (BAY 958;BAY958;LDC526)

生物&药学活性

物理化学性质&存储条件

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