BAY-826 | TIE-2 inhibitor | Probechem Biochemicals

Chemical Structure : BAY-826

CAS No.: 1448316-08-2

加入收藏

BAY-826 (BAY826)

货号: PC-35106Not For Human Use, Lab Use Only.

BAY-826 (BAY826) is a novel selective, highly potent, orally available TIE-2 inhibitor (dissociation constant=1.6 nM).

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5480	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

BAY-826 (BAY826) is a novel selective, highly potent, orally available TIE-2 inhibitor (dissociation constant=1.6 nM).
BAY-826 binds with similar high affinity to only 4 of 456 kinases, namely, TIE-1,DDR1, DDR2, and LOK (dissociation constant=0.9, 0.4, 1.3, and 5.9 nM).
BAY-826 is highly selective against other angiogenic kinases, such as VEGFR, FGFR, or PDGFR, and affects VEGF-stimulated proliferation of HUVEC only at lM concentrations.
BAY-826 inhibits TIE-2 phosphorylation in vitro and in vivo as demonstrated by suppression of Angiopoietin-1- or Na3 VO4 -induced TIE-2 phosphorylation in glioma cells or extracts of lungs from BAY-826-treated mice.
BAY-826 improves tumor control in syngeneic mouse glioma models.

物理化学性质&存储条件

分子量	558.531
分子式	C26H19F5N6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-cyano-N-(2,4-dimethyl-5-(6-(pyridin-3-yl)-1H-imidazo[1,2-b]pyrazol-1-yl)phenyl)-5-(pentafluoro-l6-sulfanyl)benzamide

参考文献

1. Schneider H, et al. J Neurochem. 2017 Jan;140(1):170-182.

BAY-826 (BAY826)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

BAY-826 (BAY826)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.