BAY-8040 (BAY8040) | Neutrophil elastase inhibitor | Probechem Biochemicals

Chemical Structure : BAY-8040

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BAY-8040 (BAY 8040, BAY8040)

货号: PC-60472Not For Human Use, Lab Use Only.

BAY-8040 (BAY8040) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM.

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生物&药学活性

BAY-8040 (BAY8040) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM.
BAY-8040 displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases.
BAY-8040 shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension.

物理化学性质&存储条件

分子量	427.387
分子式	C21H16F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(7-methyl-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyridazin-4-yl)benzonitrile

参考文献

1. von Nussbaum F, et al. ChemMedChem. 2016 Jan 19;11(2):199-206.

BAY-8040 (BAY 8040, BAY8040)

生物&药学活性

物理化学性质&存储条件

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BAY-8040 (BAY 8040, BAY8040)

生物&药学活性

物理化学性质&存储条件

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