BAY-747 | sGC stimulator | Probechem Biochemicals

Chemical Structure : BAY-747

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BAY-747 (BAY 1165747, BAY747)

货号: PC-72945Not For Human Use, Lab Use Only.

BAY-747 (BAY 1165747, BAY747) is a novel potent, selective, brain-penetrant soluble guanylate cyclase (sGC) stimulator with MEC value of 0.06 uM for stimulation of cGMP formation.

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生物&药学活性

BAY-747 (BAY 1165747, BAY747) is a novel potent, selective, brain-penetrant soluble guanylate cyclase (sGC) stimulator with MEC value of 0.06 uM for stimulation of cGMP formation.
Oral administration of BAY-747 to male Wistar rats enhanced memory acquisition in the object location task (OLT), reversed L-NAME induced memory impairments in the OLT.
BAY-747 enhanced hippocampal GluA1-containing AMPA receptor (AMPAR) trafficking in a chemical LTP model for memory acquisition using acute mouse hippocampal slices in ex vivo.

物理化学性质&存储条件

分子量	416.473
分子式	C22H26F2N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (4.2 mg/mL)
Chemical Name/SMILES	N-[(2S)-2-Amino-2-methylbutyl]-8-[(2,6-difluorophenyl)methoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxamide

参考文献

1. Nelissen E, et al. Sci Rep. 2022 Mar 4;12(1):3589.
2. Vakalopoulos A, et al. J Med Chem. 2023 Apr 11. doi: 10.1021/acs.jmedchem.2c02082.

BAY-747 (BAY 1165747, BAY747)

生物&药学活性

物理化学性质&存储条件

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BAY-747 (BAY 1165747, BAY747)

生物&药学活性

物理化学性质&存储条件

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